Insta-10!
The graphics still have that Madness style to them. I love it! Black and white, and with just the right amount of color. In some previous episodes there was too much yellow blood or other stuff, but I liked the ratio in this one a lot. The art style is good and the proportions for the weapons are believable. The flames, particle effects, and damage to the environment were spot-on!
The sound effects were good too. Realistic, nothing got too repetitive. The music did, though. Maybe you should enlist API a bit more rather than Cheshyre. :S
As for the animation... Ace work, except for the uncannily good luck that the protagonists seem to have. If they don't have guns, the agents only have bats and knives. The agents rarely have guns when the protagonists don't. I did like the things such as the protagonists bandaging up or getting weapons in between battle shots, though. The way the shots were taken were great, and I loved the comic relief when the guy in the store was reading a book. Also props to the way the protagonists communicated through charades. The way they climbed ladders with 1 hand was unrealistic, though.
On a last note I loved the new layout of the menus and buttons. The interface is super cool.